CovidSeniorV1, Main, Exploration, bibRecord, 000238

Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients.

Identifieur interne : 000238 ( Main/Exploration ); précédent : 000237; suivant : 000239

Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients.

Auteurs : Michael J. Joyner [États-Unis] ; Katelyn A. Bruno [États-Unis] ; Stephen A. Klassen [États-Unis] ; Katie L. Kunze [États-Unis] ; Patrick W. Johnson [États-Unis] ; Elizabeth R. Lesser [États-Unis] ; Chad C. Wiggins [États-Unis] ; Jonathon W. Senefeld [États-Unis] ; Allan M. Klompas [États-Unis] ; David O. Hodge [États-Unis] ; John R A. Shepherd [États-Unis] ; Robert F. Rea [États-Unis] ; Emily R. Whelan [États-Unis] ; Andrew J. Clayburn [États-Unis] ; Matthew R. Spiegel [États-Unis] ; Sarah E. Baker [États-Unis] ; Kathryn F. Larson [États-Unis] ; Juan G. Ripoll [États-Unis] ; Kylie J. Andersen [États-Unis] ; Matthew R. Buras [États-Unis] ; Matthew N P. Vogt [États-Unis] ; Vitaly Herasevich [États-Unis] ; Joshua J. Dennis [États-Unis] ; Riley J. Regimbal [États-Unis] ; Philippe R. Bauer [États-Unis] ; Janis E. Blair [États-Unis] ; Camille M. Van Buskirk [États-Unis] ; Jeffrey L. Winters [États-Unis] ; James R. Stubbs [États-Unis] ; Noud Van Helmond [États-Unis] ; Brian P. Butterfield [États-Unis] ; Matthew A. Sexton [États-Unis] ; Juan C. Diaz Soto [États-Unis] ; Nigel S. Paneth [États-Unis] ; Nicole C. Verdun [États-Unis] ; Peter Marks [États-Unis] ; Arturo Casadevall [États-Unis] ; Delisa Fairweather [États-Unis] ; Rickey E. Carter [États-Unis] ; R Scott Wright [États-Unis]

Source :

Mayo Clinic proceedings [ 1942-5546 ] ; 2020.

RBID : pubmed:32861333

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Femelle (MeSH), Hospitalisation (MeSH), Humains (MeSH), Immunisation passive (effets indésirables), Infections à coronavirus (mortalité), Infections à coronavirus (thérapie), Jeune adulte (MeSH), Maladie grave (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (mortalité), Pneumopathie virale (thérapie), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Systèmes de signalement des effets indésirables des médicaments (MeSH), Sécurité des patients (MeSH), États-Unis (MeSH).
MESH :
- effets indésirables : Immunisation passive.
- mortalité : Infections à coronavirus, Pneumopathie virale.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Hospitalisation, Humains, Jeune adulte, Maladie grave, Mâle, Pandémies, Sujet âgé, Sujet âgé de 80 ans ou plus, Systèmes de signalement des effets indésirables des médicaments, Sécurité des patients, États-Unis.
Wicri :
- geographic : États-Unis.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Adverse Drug Reaction Reporting Systems (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Critical Illness (MeSH), Female (MeSH), Hospitalization (MeSH), Humans (MeSH), Immunization, Passive (adverse effects), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Patient Safety (MeSH), Pneumonia, Viral (mortality), Pneumonia, Viral (therapy), United States (MeSH), Young Adult (MeSH).
MESH :
- geographic : United States.
- adverse effects : Immunization, Passive.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Adolescent, Adult, Adverse Drug Reaction Reporting Systems, Aged, Aged, 80 and over, Critical Illness, Female, Hospitalization, Humans, Male, Middle Aged, Pandemics, Patient Safety, Young Adult.

Abstract

OBJECTIVE

To provide an update on key safety metrics after transfusion of convalescent plasma in hospitalized coronavirus 2019 (COVID-19) patients, having previously demonstrated safety in 5000 hospitalized patients.

PATIENTS AND METHODS

From April 3 to June 2, 2020, the US Food and Drug Administration Expanded Access Program for COVID-19 convalescent plasma transfused a convenience sample of 20,000 hospitalized patients with COVID-19 convalescent plasma.

RESULTS

The incidence of all serious adverse events was low; these included transfusion reactions (n=78; <1%), thromboembolic or thrombotic events (n=113; <1%), and cardiac events (n=677, ~3%). Notably, the vast majority of the thromboembolic or thrombotic events (n=75) and cardiac events (n=597) were judged to be unrelated to the plasma transfusion per se. The 7-day mortality rate was 13.0% (12.5%, 13.4%), and was higher among more critically ill patients relative to less ill counterparts, including patients admitted to the intensive care unit versus those not admitted (15.6 vs 9.3%), mechanically ventilated versus not ventilated (18.3% vs 9.9%), and with septic shock or multiple organ dysfunction/failure versus those without dysfunction/failure (21.7% vs 11.5%).

CONCLUSION

These updated data provide robust evidence that transfusion of convalescent plasma is safe in hospitalized patients with COVID-19, and support the notion that earlier administration of plasma within the clinical course of COVID-19 is more likely to reduce mortality.

DOI: 10.1016/j.mayocp.2020.06.028
PubMed: 32861333
PubMed Central: PMC7368917

Affiliations:

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Le document en format XML

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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
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<wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Scottsdale</wicri:cityArea>
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<author><name sortKey="Vogt, Matthew N P" sort="Vogt, Matthew N P" uniqKey="Vogt M" first="Matthew N P" last="Vogt">Matthew N P. Vogt</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
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</author>
<author><name sortKey="Herasevich, Vitaly" sort="Herasevich, Vitaly" uniqKey="Herasevich V" first="Vitaly" last="Herasevich">Vitaly Herasevich</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
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<author><name sortKey="Dennis, Joshua J" sort="Dennis, Joshua J" uniqKey="Dennis J" first="Joshua J" last="Dennis">Joshua J. Dennis</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Regimbal, Riley J" sort="Regimbal, Riley J" uniqKey="Regimbal R" first="Riley J" last="Regimbal">Riley J. Regimbal</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
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<author><name sortKey="Bauer, Philippe R" sort="Bauer, Philippe R" uniqKey="Bauer P" first="Philippe R" last="Bauer">Philippe R. Bauer</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Division of Pulmonary and Critical Care, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Blair, Janis E" sort="Blair, Janis E" uniqKey="Blair J" first="Janis E" last="Blair">Janis E. Blair</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Division of Infectious Diseases, Mayo Clinic, Phoenix, AZ.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Division of Infectious Diseases, Mayo Clinic, Phoenix</wicri:cityArea>
</affiliation>
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<author><name sortKey="Van Buskirk, Camille M" sort="Van Buskirk, Camille M" uniqKey="Van Buskirk C" first="Camille M" last="Van Buskirk">Camille M. Van Buskirk</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Winters, Jeffrey L" sort="Winters, Jeffrey L" uniqKey="Winters J" first="Jeffrey L" last="Winters">Jeffrey L. Winters</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stubbs, James R" sort="Stubbs, James R" uniqKey="Stubbs J" first="James R" last="Stubbs">James R. Stubbs</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van Helmond, Noud" sort="Van Helmond, Noud" uniqKey="Van Helmond N" first="Noud" last="Van Helmond">Noud Van Helmond</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University Health Care, Camden, NJ.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University Health Care, Camden</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Butterfield, Brian P" sort="Butterfield, Brian P" uniqKey="Butterfield B" first="Brian P" last="Butterfield">Brian P. Butterfield</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sexton, Matthew A" sort="Sexton, Matthew A" uniqKey="Sexton M" first="Matthew A" last="Sexton">Matthew A. Sexton</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Diaz Soto, Juan C" sort="Diaz Soto, Juan C" uniqKey="Diaz Soto J" first="Juan C" last="Diaz Soto">Juan C. Diaz Soto</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Paneth, Nigel S" sort="Paneth, Nigel S" uniqKey="Paneth N" first="Nigel S" last="Paneth">Nigel S. Paneth</name>
<affiliation wicri:level="4"><nlm:affiliation>Departments of Epidemiology and Biostatistics and Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing.</nlm:affiliation>
<orgName type="university">Université d'État du Michigan</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">East Lansing</settlement>
<region type="state">Michigan</region>
</placeName>
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</author>
<author><name sortKey="Verdun, Nicole C" sort="Verdun, Nicole C" uniqKey="Verdun N" first="Nicole C" last="Verdun">Nicole C. Verdun</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring</wicri:cityArea>
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<author><name sortKey="Marks, Peter" sort="Marks, Peter" uniqKey="Marks P" first="Peter" last="Marks">Peter Marks</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Casadevall, Arturo" sort="Casadevall, Arturo" uniqKey="Casadevall A" first="Arturo" last="Casadevall">Arturo Casadevall</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fairweather, Delisa" sort="Fairweather, Delisa" uniqKey="Fairweather D" first="Delisa" last="Fairweather">Delisa Fairweather</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Carter, Rickey E" sort="Carter, Rickey E" uniqKey="Carter R" first="Rickey E" last="Carter">Rickey E. Carter</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wright, R Scott" sort="Wright, R Scott" uniqKey="Wright R" first="R Scott" last="Wright">R Scott Wright</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN; Department of Human Research Protection Program, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN; Department of Human Research Protection Program, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
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<idno type="pmid">32861333</idno>
<idno type="doi">10.1016/j.mayocp.2020.06.028</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients.</title>
<author><name sortKey="Joyner, Michael J" sort="Joyner, Michael J" uniqKey="Joyner M" first="Michael J" last="Joyner">Michael J. Joyner</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN. Electronic address: https://twitter.com/DrMJoyner.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bruno, Katelyn A" sort="Bruno, Katelyn A" uniqKey="Bruno K" first="Katelyn A" last="Bruno">Katelyn A. Bruno</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Klassen, Stephen A" sort="Klassen, Stephen A" uniqKey="Klassen S" first="Stephen A" last="Klassen">Stephen A. Klassen</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kunze, Katie L" sort="Kunze, Katie L" uniqKey="Kunze K" first="Katie L" last="Kunze">Katie L. Kunze</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Scottsdale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Johnson, Patrick W" sort="Johnson, Patrick W" uniqKey="Johnson P" first="Patrick W" last="Johnson">Patrick W. Johnson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lesser, Elizabeth R" sort="Lesser, Elizabeth R" uniqKey="Lesser E" first="Elizabeth R" last="Lesser">Elizabeth R. Lesser</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wiggins, Chad C" sort="Wiggins, Chad C" uniqKey="Wiggins C" first="Chad C" last="Wiggins">Chad C. Wiggins</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Senefeld, Jonathon W" sort="Senefeld, Jonathon W" uniqKey="Senefeld J" first="Jonathon W" last="Senefeld">Jonathon W. Senefeld</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Klompas, Allan M" sort="Klompas, Allan M" uniqKey="Klompas A" first="Allan M" last="Klompas">Allan M. Klompas</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hodge, David O" sort="Hodge, David O" uniqKey="Hodge D" first="David O" last="Hodge">David O. Hodge</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shepherd, John R A" sort="Shepherd, John R A" uniqKey="Shepherd J" first="John R A" last="Shepherd">John R A. Shepherd</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rea, Robert F" sort="Rea, Robert F" uniqKey="Rea R" first="Robert F" last="Rea">Robert F. Rea</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Cardiovascular Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Whelan, Emily R" sort="Whelan, Emily R" uniqKey="Whelan E" first="Emily R" last="Whelan">Emily R. Whelan</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Clayburn, Andrew J" sort="Clayburn, Andrew J" uniqKey="Clayburn A" first="Andrew J" last="Clayburn">Andrew J. Clayburn</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Spiegel, Matthew R" sort="Spiegel, Matthew R" uniqKey="Spiegel M" first="Matthew R" last="Spiegel">Matthew R. Spiegel</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Baker, Sarah E" sort="Baker, Sarah E" uniqKey="Baker S" first="Sarah E" last="Baker">Sarah E. Baker</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Larson, Kathryn F" sort="Larson, Kathryn F" uniqKey="Larson K" first="Kathryn F" last="Larson">Kathryn F. Larson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ripoll, Juan G" sort="Ripoll, Juan G" uniqKey="Ripoll J" first="Juan G" last="Ripoll">Juan G. Ripoll</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Andersen, Kylie J" sort="Andersen, Kylie J" uniqKey="Andersen K" first="Kylie J" last="Andersen">Kylie J. Andersen</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Buras, Matthew R" sort="Buras, Matthew R" uniqKey="Buras M" first="Matthew R" last="Buras">Matthew R. Buras</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Scottsdale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Vogt, Matthew N P" sort="Vogt, Matthew N P" uniqKey="Vogt M" first="Matthew N P" last="Vogt">Matthew N P. Vogt</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Herasevich, Vitaly" sort="Herasevich, Vitaly" uniqKey="Herasevich V" first="Vitaly" last="Herasevich">Vitaly Herasevich</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dennis, Joshua J" sort="Dennis, Joshua J" uniqKey="Dennis J" first="Joshua J" last="Dennis">Joshua J. Dennis</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Regimbal, Riley J" sort="Regimbal, Riley J" uniqKey="Regimbal R" first="Riley J" last="Regimbal">Riley J. Regimbal</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bauer, Philippe R" sort="Bauer, Philippe R" uniqKey="Bauer P" first="Philippe R" last="Bauer">Philippe R. Bauer</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Division of Pulmonary and Critical Care, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Blair, Janis E" sort="Blair, Janis E" uniqKey="Blair J" first="Janis E" last="Blair">Janis E. Blair</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Division of Infectious Diseases, Mayo Clinic, Phoenix, AZ.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Division of Infectious Diseases, Mayo Clinic, Phoenix</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van Buskirk, Camille M" sort="Van Buskirk, Camille M" uniqKey="Van Buskirk C" first="Camille M" last="Van Buskirk">Camille M. Van Buskirk</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Winters, Jeffrey L" sort="Winters, Jeffrey L" uniqKey="Winters J" first="Jeffrey L" last="Winters">Jeffrey L. Winters</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stubbs, James R" sort="Stubbs, James R" uniqKey="Stubbs J" first="James R" last="Stubbs">James R. Stubbs</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van Helmond, Noud" sort="Van Helmond, Noud" uniqKey="Van Helmond N" first="Noud" last="Van Helmond">Noud Van Helmond</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University Health Care, Camden, NJ.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University Health Care, Camden</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Butterfield, Brian P" sort="Butterfield, Brian P" uniqKey="Butterfield B" first="Brian P" last="Butterfield">Brian P. Butterfield</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sexton, Matthew A" sort="Sexton, Matthew A" uniqKey="Sexton M" first="Matthew A" last="Sexton">Matthew A. Sexton</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Diaz Soto, Juan C" sort="Diaz Soto, Juan C" uniqKey="Diaz Soto J" first="Juan C" last="Diaz Soto">Juan C. Diaz Soto</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Paneth, Nigel S" sort="Paneth, Nigel S" uniqKey="Paneth N" first="Nigel S" last="Paneth">Nigel S. Paneth</name>
<affiliation wicri:level="4"><nlm:affiliation>Departments of Epidemiology and Biostatistics and Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing.</nlm:affiliation>
<orgName type="university">Université d'État du Michigan</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">East Lansing</settlement>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Verdun, Nicole C" sort="Verdun, Nicole C" uniqKey="Verdun N" first="Nicole C" last="Verdun">Nicole C. Verdun</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marks, Peter" sort="Marks, Peter" uniqKey="Marks P" first="Peter" last="Marks">Peter Marks</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Casadevall, Arturo" sort="Casadevall, Arturo" uniqKey="Casadevall A" first="Arturo" last="Casadevall">Arturo Casadevall</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fairweather, Delisa" sort="Fairweather, Delisa" uniqKey="Fairweather D" first="Delisa" last="Fairweather">Delisa Fairweather</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Carter, Rickey E" sort="Carter, Rickey E" uniqKey="Carter R" first="Rickey E" last="Carter">Rickey E. Carter</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wright, R Scott" sort="Wright, R Scott" uniqKey="Wright R" first="R Scott" last="Wright">R Scott Wright</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN; Department of Human Research Protection Program, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN; Department of Human Research Protection Program, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Mayo Clinic proceedings</title>
<idno type="eISSN">1942-5546</idno>
<imprint><date when="2020" type="published">2020</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Adverse Drug Reaction Reporting Systems (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Critical Illness (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hospitalization (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunization, Passive (adverse effects)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Patient Safety (MeSH)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>United States (MeSH)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Hospitalisation (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunisation passive (effets indésirables)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Infections à coronavirus (thérapie)</term>
<term>Jeune adulte (MeSH)</term>
<term>Maladie grave (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Systèmes de signalement des effets indésirables des médicaments (MeSH)</term>
<term>Sécurité des patients (MeSH)</term>
<term>États-Unis (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>United States</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Immunization, Passive</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Immunisation passive</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Adverse Drug Reaction Reporting Systems</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Critical Illness</term>
<term>Female</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Patient Safety</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Maladie grave</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Systèmes de signalement des effets indésirables des médicaments</term>
<term>Sécurité des patients</term>
<term>États-Unis</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To provide an update on key safety metrics after transfusion of convalescent plasma in hospitalized coronavirus 2019 (COVID-19) patients, having previously demonstrated safety in 5000 hospitalized patients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>PATIENTS AND METHODS</b>
</p>
<p>From April 3 to June 2, 2020, the US Food and Drug Administration Expanded Access Program for COVID-19 convalescent plasma transfused a convenience sample of 20,000 hospitalized patients with COVID-19 convalescent plasma.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>The incidence of all serious adverse events was low; these included transfusion reactions (n=78; <1%), thromboembolic or thrombotic events (n=113; <1%), and cardiac events (n=677, ~3%). Notably, the vast majority of the thromboembolic or thrombotic events (n=75) and cardiac events (n=597) were judged to be unrelated to the plasma transfusion per se. The 7-day mortality rate was 13.0% (12.5%, 13.4%), and was higher among more critically ill patients relative to less ill counterparts, including patients admitted to the intensive care unit versus those not admitted (15.6 vs 9.3%), mechanically ventilated versus not ventilated (18.3% vs 9.9%), and with septic shock or multiple organ dysfunction/failure versus those without dysfunction/failure (21.7% vs 11.5%).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>These updated data provide robust evidence that transfusion of convalescent plasma is safe in hospitalized patients with COVID-19, and support the notion that earlier administration of plasma within the clinical course of COVID-19 is more likely to reduce mortality.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32861333</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>12</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1942-5546</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>95</Volume>
<Issue>9</Issue>
<PubDate><Year>2020</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>Mayo Clinic proceedings</Title>
<ISOAbbreviation>Mayo Clin Proc</ISOAbbreviation>
</Journal>
<ArticleTitle>Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients.</ArticleTitle>
<Pagination><MedlinePgn>1888-1897</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0025-6196(20)30651-0</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.mayocp.2020.06.028</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE">To provide an update on key safety metrics after transfusion of convalescent plasma in hospitalized coronavirus 2019 (COVID-19) patients, having previously demonstrated safety in 5000 hospitalized patients.</AbstractText>
<AbstractText Label="PATIENTS AND METHODS">From April 3 to June 2, 2020, the US Food and Drug Administration Expanded Access Program for COVID-19 convalescent plasma transfused a convenience sample of 20,000 hospitalized patients with COVID-19 convalescent plasma.</AbstractText>
<AbstractText Label="RESULTS">The incidence of all serious adverse events was low; these included transfusion reactions (n=78; <1%), thromboembolic or thrombotic events (n=113; <1%), and cardiac events (n=677, ~3%). Notably, the vast majority of the thromboembolic or thrombotic events (n=75) and cardiac events (n=597) were judged to be unrelated to the plasma transfusion per se. The 7-day mortality rate was 13.0% (12.5%, 13.4%), and was higher among more critically ill patients relative to less ill counterparts, including patients admitted to the intensive care unit versus those not admitted (15.6 vs 9.3%), mechanically ventilated versus not ventilated (18.3% vs 9.9%), and with septic shock or multiple organ dysfunction/failure versus those without dysfunction/failure (21.7% vs 11.5%).</AbstractText>
<AbstractText Label="CONCLUSION">These updated data provide robust evidence that transfusion of convalescent plasma is safe in hospitalized patients with COVID-19, and support the notion that earlier administration of plasma within the clinical course of COVID-19 is more likely to reduce mortality.</AbstractText>
<CopyrightInformation>Copyright © 2020. Published by Elsevier Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Joyner</LastName>
<ForeName>Michael J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN. Electronic address: https://twitter.com/DrMJoyner.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bruno</LastName>
<ForeName>Katelyn A</ForeName>
<Initials>KA</Initials>
<AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klassen</LastName>
<ForeName>Stephen A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kunze</LastName>
<ForeName>Katie L</ForeName>
<Initials>KL</Initials>
<AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Johnson</LastName>
<ForeName>Patrick W</ForeName>
<Initials>PW</Initials>
<AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lesser</LastName>
<ForeName>Elizabeth R</ForeName>
<Initials>ER</Initials>
<AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wiggins</LastName>
<ForeName>Chad C</ForeName>
<Initials>CC</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Senefeld</LastName>
<ForeName>Jonathon W</ForeName>
<Initials>JW</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klompas</LastName>
<ForeName>Allan M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hodge</LastName>
<ForeName>David O</ForeName>
<Initials>DO</Initials>
<AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shepherd</LastName>
<ForeName>John R A</ForeName>
<Initials>JRA</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rea</LastName>
<ForeName>Robert F</ForeName>
<Initials>RF</Initials>
<AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Whelan</LastName>
<ForeName>Emily R</ForeName>
<Initials>ER</Initials>
<AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Clayburn</LastName>
<ForeName>Andrew J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Spiegel</LastName>
<ForeName>Matthew R</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baker</LastName>
<ForeName>Sarah E</ForeName>
<Initials>SE</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Larson</LastName>
<ForeName>Kathryn F</ForeName>
<Initials>KF</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ripoll</LastName>
<ForeName>Juan G</ForeName>
<Initials>JG</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Andersen</LastName>
<ForeName>Kylie J</ForeName>
<Initials>KJ</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Buras</LastName>
<ForeName>Matthew R</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vogt</LastName>
<ForeName>Matthew N P</ForeName>
<Initials>MNP</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Herasevich</LastName>
<ForeName>Vitaly</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dennis</LastName>
<ForeName>Joshua J</ForeName>
<Initials>JJ</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Regimbal</LastName>
<ForeName>Riley J</ForeName>
<Initials>RJ</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bauer</LastName>
<ForeName>Philippe R</ForeName>
<Initials>PR</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blair</LastName>
<ForeName>Janis E</ForeName>
<Initials>JE</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Infectious Diseases, Mayo Clinic, Phoenix, AZ.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Buskirk</LastName>
<ForeName>Camille M</ForeName>
<Initials>CM</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Winters</LastName>
<ForeName>Jeffrey L</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stubbs</LastName>
<ForeName>James R</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Helmond</LastName>
<ForeName>Noud</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University Health Care, Camden, NJ.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Butterfield</LastName>
<ForeName>Brian P</ForeName>
<Initials>BP</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sexton</LastName>
<ForeName>Matthew A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Diaz Soto</LastName>
<ForeName>Juan C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Paneth</LastName>
<ForeName>Nigel S</ForeName>
<Initials>NS</Initials>
<AffiliationInfo><Affiliation>Departments of Epidemiology and Biostatistics and Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Verdun</LastName>
<ForeName>Nicole C</ForeName>
<Initials>NC</Initials>
<AffiliationInfo><Affiliation>Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marks</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Casadevall</LastName>
<ForeName>Arturo</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fairweather</LastName>
<ForeName>DeLisa</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carter</LastName>
<ForeName>Rickey E</ForeName>
<Initials>RE</Initials>
<AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wright</LastName>
<ForeName>R Scott</ForeName>
<Initials>RS</Initials>
<AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN; Department of Human Research Protection Program, Mayo Clinic, Rochester, MN.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>75A50120C00096</GrantID>
<Acronym>HH</Acronym>
<Agency>HHS</Agency>
<Country>United States</Country>
</Grant>
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<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>07</Month>
<Day>19</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Mayo Clin Proc</MedlineTA>
<NlmUniqueID>0405543</NlmUniqueID>
<ISSNLinking>0025-6196</ISSNLinking>
</MedlineJournalInfo>
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<SupplMeshName Type="Protocol" UI="C000705128">COVID-19 serotherapy</SupplMeshName>
</SupplMeshList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016907" MajorTopicYN="N">Adverse Drug Reaction Reporting Systems</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007116" MajorTopicYN="N">Immunization, Passive</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061214" MajorTopicYN="Y">Patient Safety</DescriptorName>
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<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
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<Month>06</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>06</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>06</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>8</Month>
<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Month>9</Month>
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<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Arizona</li>
<li>Floride</li>
<li>Maryland</li>
<li>Michigan</li>
<li>Minnesota</li>
<li>New Jersey</li>
</region>
<settlement><li>East Lansing</li>
</settlement>
<orgName><li>Université d'État du Michigan</li>
</orgName>
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<tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Joyner, Michael J" sort="Joyner, Michael J" uniqKey="Joyner M" first="Michael J" last="Joyner">Michael J. Joyner</name>
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<name sortKey="Andersen, Kylie J" sort="Andersen, Kylie J" uniqKey="Andersen K" first="Kylie J" last="Andersen">Kylie J. Andersen</name>
<name sortKey="Baker, Sarah E" sort="Baker, Sarah E" uniqKey="Baker S" first="Sarah E" last="Baker">Sarah E. Baker</name>
<name sortKey="Bauer, Philippe R" sort="Bauer, Philippe R" uniqKey="Bauer P" first="Philippe R" last="Bauer">Philippe R. Bauer</name>
<name sortKey="Blair, Janis E" sort="Blair, Janis E" uniqKey="Blair J" first="Janis E" last="Blair">Janis E. Blair</name>
<name sortKey="Bruno, Katelyn A" sort="Bruno, Katelyn A" uniqKey="Bruno K" first="Katelyn A" last="Bruno">Katelyn A. Bruno</name>
<name sortKey="Buras, Matthew R" sort="Buras, Matthew R" uniqKey="Buras M" first="Matthew R" last="Buras">Matthew R. Buras</name>
<name sortKey="Butterfield, Brian P" sort="Butterfield, Brian P" uniqKey="Butterfield B" first="Brian P" last="Butterfield">Brian P. Butterfield</name>
<name sortKey="Carter, Rickey E" sort="Carter, Rickey E" uniqKey="Carter R" first="Rickey E" last="Carter">Rickey E. Carter</name>
<name sortKey="Casadevall, Arturo" sort="Casadevall, Arturo" uniqKey="Casadevall A" first="Arturo" last="Casadevall">Arturo Casadevall</name>
<name sortKey="Clayburn, Andrew J" sort="Clayburn, Andrew J" uniqKey="Clayburn A" first="Andrew J" last="Clayburn">Andrew J. Clayburn</name>
<name sortKey="Dennis, Joshua J" sort="Dennis, Joshua J" uniqKey="Dennis J" first="Joshua J" last="Dennis">Joshua J. Dennis</name>
<name sortKey="Diaz Soto, Juan C" sort="Diaz Soto, Juan C" uniqKey="Diaz Soto J" first="Juan C" last="Diaz Soto">Juan C. Diaz Soto</name>
<name sortKey="Fairweather, Delisa" sort="Fairweather, Delisa" uniqKey="Fairweather D" first="Delisa" last="Fairweather">Delisa Fairweather</name>
<name sortKey="Herasevich, Vitaly" sort="Herasevich, Vitaly" uniqKey="Herasevich V" first="Vitaly" last="Herasevich">Vitaly Herasevich</name>
<name sortKey="Hodge, David O" sort="Hodge, David O" uniqKey="Hodge D" first="David O" last="Hodge">David O. Hodge</name>
<name sortKey="Johnson, Patrick W" sort="Johnson, Patrick W" uniqKey="Johnson P" first="Patrick W" last="Johnson">Patrick W. Johnson</name>
<name sortKey="Klassen, Stephen A" sort="Klassen, Stephen A" uniqKey="Klassen S" first="Stephen A" last="Klassen">Stephen A. Klassen</name>
<name sortKey="Klompas, Allan M" sort="Klompas, Allan M" uniqKey="Klompas A" first="Allan M" last="Klompas">Allan M. Klompas</name>
<name sortKey="Kunze, Katie L" sort="Kunze, Katie L" uniqKey="Kunze K" first="Katie L" last="Kunze">Katie L. Kunze</name>
<name sortKey="Larson, Kathryn F" sort="Larson, Kathryn F" uniqKey="Larson K" first="Kathryn F" last="Larson">Kathryn F. Larson</name>
<name sortKey="Lesser, Elizabeth R" sort="Lesser, Elizabeth R" uniqKey="Lesser E" first="Elizabeth R" last="Lesser">Elizabeth R. Lesser</name>
<name sortKey="Marks, Peter" sort="Marks, Peter" uniqKey="Marks P" first="Peter" last="Marks">Peter Marks</name>
<name sortKey="Paneth, Nigel S" sort="Paneth, Nigel S" uniqKey="Paneth N" first="Nigel S" last="Paneth">Nigel S. Paneth</name>
<name sortKey="Rea, Robert F" sort="Rea, Robert F" uniqKey="Rea R" first="Robert F" last="Rea">Robert F. Rea</name>
<name sortKey="Regimbal, Riley J" sort="Regimbal, Riley J" uniqKey="Regimbal R" first="Riley J" last="Regimbal">Riley J. Regimbal</name>
<name sortKey="Ripoll, Juan G" sort="Ripoll, Juan G" uniqKey="Ripoll J" first="Juan G" last="Ripoll">Juan G. Ripoll</name>
<name sortKey="Senefeld, Jonathon W" sort="Senefeld, Jonathon W" uniqKey="Senefeld J" first="Jonathon W" last="Senefeld">Jonathon W. Senefeld</name>
<name sortKey="Sexton, Matthew A" sort="Sexton, Matthew A" uniqKey="Sexton M" first="Matthew A" last="Sexton">Matthew A. Sexton</name>
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<name sortKey="Spiegel, Matthew R" sort="Spiegel, Matthew R" uniqKey="Spiegel M" first="Matthew R" last="Spiegel">Matthew R. Spiegel</name>
<name sortKey="Stubbs, James R" sort="Stubbs, James R" uniqKey="Stubbs J" first="James R" last="Stubbs">James R. Stubbs</name>
<name sortKey="Van Buskirk, Camille M" sort="Van Buskirk, Camille M" uniqKey="Van Buskirk C" first="Camille M" last="Van Buskirk">Camille M. Van Buskirk</name>
<name sortKey="Van Helmond, Noud" sort="Van Helmond, Noud" uniqKey="Van Helmond N" first="Noud" last="Van Helmond">Noud Van Helmond</name>
<name sortKey="Verdun, Nicole C" sort="Verdun, Nicole C" uniqKey="Verdun N" first="Nicole C" last="Verdun">Nicole C. Verdun</name>
<name sortKey="Vogt, Matthew N P" sort="Vogt, Matthew N P" uniqKey="Vogt M" first="Matthew N P" last="Vogt">Matthew N P. Vogt</name>
<name sortKey="Whelan, Emily R" sort="Whelan, Emily R" uniqKey="Whelan E" first="Emily R" last="Whelan">Emily R. Whelan</name>
<name sortKey="Wiggins, Chad C" sort="Wiggins, Chad C" uniqKey="Wiggins C" first="Chad C" last="Wiggins">Chad C. Wiggins</name>
<name sortKey="Winters, Jeffrey L" sort="Winters, Jeffrey L" uniqKey="Winters J" first="Jeffrey L" last="Winters">Jeffrey L. Winters</name>
<name sortKey="Wright, R Scott" sort="Wright, R Scott" uniqKey="Wright R" first="R Scott" last="Wright">R Scott Wright</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidSeniorV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000238 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000238 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    CovidSeniorV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:32861333
   |texte=   Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:32861333" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidSeniorV1

This area was generated with Dilib version V0.6.37.
Data generation: Thu Oct 15 09:49:45 2020. Site generation: Wed Jan 27 17:10:23 2021

	Serveur d'exploration sur la COVID chez les séniors
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la COVID chez les séniors

Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients.

Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki